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The Difference Between Suboxone® & Belbuca

Jeremy Dubin
Clinically Reviewed By Dr. Jeremy Dubin

Belbuca and Suboxone® both contain buprenorphine, which is classified as a partial opioid agonist. This means they both work by interacting with the body’s opioid receptors, though in a way that is designed to minimize the risk of addiction and misuse compared to full opioid agonists like morphine or oxycodone. Despite these similarities, it’s important to note that these medications are distinct from one another. Although they’re both opioids, Belbuca is primarily used for chronic pain management, whereas Suboxone® is utilized in the treatment and management of opioid dependence. Understanding the unique aspects of each medication can be important for making informed treatment decisions.

What is Belbuca?

Belbuca is a prescription medication that utilizes buprenorphine as the active ingredient, a partial opioid agonist known for its efficacy in pain management and opioid dependence treatment. Belbuca’s formulation is designed to bind to the same brain receptors as other opioids but with a significantly reduced risk of producing euphoric effects, thereby lowering the potential for misuse and addiction. This property makes it an invaluable tool in the management of chronic pain, offering sustained relief without the highs and lows associated with stronger opioids.

Is Belbuca the Same as Suboxone®?

Although Belbuca and Suboxone® both contain buprenorphine, they are not the same medication and serve different primary purposes in medical treatment. Some of the key differences between these two medicines include:

  • Intended Use: Belbuca is approved for chronic pain management, while Suboxone® is formulated to assist in the recovery from opioid addiction by reducing withdrawal symptoms and curbing cravings.
  • Formulation: Suboxone®’s inclusion of naloxone differentiates it significantly from Belbuca. Naloxone is intended to deter the intravenous misuse of the drug, a feature not present in Belbuca.
  • Administration Method: Belbuca is administered as a buccal film, whereas Suboxone® is available in sublingual tablet or film form, designed to be placed under the tongue or inside the cheek.
  • Regulatory Approval: Health authorities have approved each medication for its specific use, with Suboxone® being recognized for its role in treating opioid use disorder (OUD), and Belbuca for pain management.

These distinctions make Suboxone® and Belbuca non-interchangeable, specifically designed to meet two separate medical needs. Be sure to consult with your healthcare provider if you have questions about your medication.

Side Effects of Belbuca

Belbuca has the potential to offer significant relief for those dealing with long-term pain. However, like all medications, it has potential side effects. Patients and healthcare providers should weigh the benefits of pain relief against these possible adverse effects to ensure safe and effective treatment. Here are some of the common and notable side effects associated with Belbuca:

  • Nausea and vomiting
  • Headache
  • Dizziness and drowsiness
  • Constipation
  • Dry mouth
  • Fatigue
  • Sweating
  • Mouth irritation where the film is applied
  • Difficulty sleeping

Patients should always communicate openly with their healthcare provider about any side effects they experience while using Belbuca. Sometimes, side effects can be managed through dose adjustments, supportive care, or additional treatments. 

What is Suboxone®?

Suboxone® combines buprenorphine with naloxone, offering a strong defense against opioid addiction. This combination not only helps alleviate withdrawal symptoms but also incorporates naloxone to prevent misuse, particularly when tampered with. Recognized for its effectiveness in long-term opioid addiction management, Suboxone®’s qualities make it a preferred Medication for Addiction Treatment (MAT) choice for many healthcare providers.

Benefits of Suboxone®

  • Alleviates Withdrawal Symptoms: Eases the transition away from opioid dependency.
  • Mitigates Misuse: Naloxone’s presence deters non-prescribed use, lowering overdose risks.
  • Craving Reduction: Lessens cravings for opioid use, aiding in relapse prevention.
  • Blocks Euphoric Effects: Diminishes the attractiveness of using opioids.
  • Extended Duration: Offers prolonged support in recovery efforts.
  • Supports Comprehensive Treatment: Works best in conjunction with counseling and therapy.

Side Effects of Suboxone®

Suboxone® can play a pivotal role in the recovery process but still has the possibility of side effects. While on Suboxone®, patients may experience a range of side effects, which are important to recognize and manage with a trained healthcare provider. Below are some of the common side effects associated with Suboxone®:

  • Nausea and vomiting
  • Headache
  • Sweating
  • Constipation
  • Insomnia
  • Mouth numbness or redness
  • Painful tongue
  • Dizziness and drowsiness
  • Respiratory issues

Belbuca vs. Suboxone® For Long-Term Use

As mentioned, Belbuca and Suboxone®, while both incorporating buprenorphine, are tailored for distinctly different medical needs. When it comes to long-term pain management and recovery from opioid addiction, these medications serve a particular purpose.

Suboxone® for Long-Term Maintenance of OUD

The presence of naloxone in Suboxone® acts as a critical deterrent against the misuse of the medication, particularly via injection, as naloxone can precipitate withdrawal symptoms when Suboxone® is misused. This safety mechanism positions Suboxone® as a preferred choice for the long-term treatment of OUD, providing a balanced approach to reduce cravings and withdrawal symptoms while minimizing the potential for misuse.

The dual-action formula of Suboxone® not only facilitates a smoother recovery process from opioid dependence but can also support engagement in complementary treatment modalities, such as counseling and behavioral therapies. Its approval and continued use highlight its effectiveness and safety profile for patients navigating the complexities of addiction recovery over extended periods.

Belbuca for Long-Term Management of Chronic Pain

Unlike Suboxone®, Belbuca is specifically formulated for chronic pain management, offering a specific buccal film delivery of buprenorphine that ensures steady medication absorption for long-lasting pain relief. Its design caters to patients who require consistent opioid-level analgesia for conditions not adequately addressed by other treatments. However, unlike Suboxone®, Belbuca does not include naloxone, as its primary purpose is not to treat opioid addiction but to manage pain with a lower risk of dependency compared to full opioid agonists.

While Belbuca’s partial agonist properties reduce the likelihood of euphoria and subsequent misuse, the absence of naloxone means that the potential for misuse, though lower than traditional opioids, necessitates monitoring in long-term use. Healthcare providers should assess the risk-benefit ratio closely, especially for patients with a history of substance abuse and misuse, to ensure that Belbuca is a safe and effective option for chronic pain management.

Which is Better, Belbuca or Suboxone®?

The decision between Belbuca and Suboxone® hinges on individual needs—whether the primary concern is chronic pain management or overcoming opioid addiction. For patients with chronic pain, especially those with a history of OUD, healthcare providers might consider Suboxone® as part of a comprehensive pain management plan. This consideration is typically based on a careful assessment of the patient’s medical history, pain management needs, and risk factors for opioid misuse. Consulting with healthcare professionals is critical when selecting the most appropriate medication and ensuring a personalized approach to recovery and pain management.

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Porch Light Health Can Help

Porch Light Health, with operations in Colorado and New Mexico, stands at the forefront of combating opioid addiction through innovative and accessible treatment solutions, including mobile clinics and telehealth. Specializing in addiction treatment at MAT, Porch Light Health provides a comprehensive approach to recovery from OUD, blending medical expertise with compassionate care to support individuals on their journey toward healing.

Ready to take the first step toward recovery? Contact Porch Light Health today to explore how MAT can be part of your journey to a healthier life. 
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