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Sublocade vs. Suboxone®: What’s The Difference?

Jeremy Dubin
Clinically Reviewed By Dr. Jeremy Dubin

Finding an effective and sustainable treatment option for individuals struggling with opioid dependency is an important part of reducing harm to those affected by the opioid epidemic. Among the many treatments available for opioid use disorder (OUD), Sublocade and Suboxone® stand out as two promising options. But how do they compare, and more importantly, how do you choose between them? 

Understanding Buprenorphine

Before exploring the specific treatments of Sublocade and Suboxone®, it’s crucial to understand buprenorphine, the active ingredient in both medications. Buprenorphine is a partial opioid agonist, meaning it binds to the same receptors in the brain as other opioids but produces a much weaker effect. This action helps to mitigate cravings and withdrawal symptoms associated with opioid addiction without the mind-altering effects associated with opioid abuse. Its unique pharmacological profile makes buprenorphine an essential component in the treatment of opioid use disorder (OUD), offering a balance between efficacy in reducing opioid use and a lower risk of misuse and dependency.

What is Sublocade?

Sublocade is an advanced treatment option for opioid addiction, marking a departure from traditional daily-dose medications. It is an injectable form of buprenorphine specifically designed for individuals diagnosed with OUD. The key distinguishing feature of Sublocade lies in its method of administration and delivery of the medication within the body.

Distinguishing Features of Sublocade:

  • How Do You Take Sublocade? Sublocade is given as a monthly injection by a healthcare provider, simplifying the treatment regimen by eliminating the need for daily medication.
  • How Does it Work? Upon injection, Sublocade slowly releases buprenorphine into the bloodstream over a month, providing a steady and controlled medication level. This continuous exposure to buprenorphine is crucial for managing withdrawal symptoms and reducing opioid cravings effectively.
  • How Effective Is It? Health authorities have endorsed Sublocade for OUD treatment due to its efficacy in maintaining therapeutic levels of buprenorphine, thereby aiding individuals in their recovery journey.

By leveraging buprenorphine’s pharmacological effects through an innovative method, Sublocade offers a compelling option for those seeking a manageable and less frequent treatment solution for opioid dependence.

How Sublocade Works

Sublocade is administered as a monthly injection by a healthcare professional. Once injected, it forms a gel-like depot under the skin, slowly releasing buprenorphine into the bloodstream over a month. This steady release mechanism ensures a constant level of medication in your body, helping to curb cravings and withdrawal symptoms associated with opioid dependence.

Benefits of Sublocade

  • Consistency: The once-a-month injection provides a constant therapeutic level of buprenorphine, reducing the daily fluctuations in mood and cravings that can be challenging during recovery.
  • Convenience: It eliminates the need for daily medication, making it easier to stay on track with treatment, especially for individuals with busy schedules or those who may struggle with daily medication adherence.
  • Reduced Stigma: By removing the daily routine of taking medication, individuals may feel a sense of normalcy, reducing the stigma often associated with addiction treatment.

What is Suboxone®?

Suboxone® is a name that’s become intertwined with opioid addiction treatment over the years. It combines two powerful components: buprenorphine and naloxone. This combination serves a dual purpose: managing withdrawal symptoms and cravings and acting as a deterrent against misuse.

Find a Suboxone® Doctor in Colorado

How Suboxone® Works

Like Sublocade, Suboxone® contains buprenorphine, which helps reduce cravings and withdrawal by acting on opioid receptors without the high. However, Suboxone® differs from Sublocade as it also contains naloxone, which counters opioid effects to prevent misuse if injected. 

Benefits of Suboxone®

  • Flexibility: The daily administration of Suboxone® allows for flexibility and dose adjustments based on individual needs and recovery progress.
  • Accessibility: Suboxone® can be prescribed by certified doctors and taken at home, making it a widely accessible option for those in treatment.
  • Safety Net: The presence of naloxone in Suboxone® acts as a deterrent for misuse, making it a safer option for individuals at risk of relapse.

Ultimately, both Sublocade and Suboxone® offer paths to recovery, each with unique benefits that cater to different needs and lifestyles. The choice between them should be made alongside a medical provider, considering personal circumstances, treatment goals, and lifestyle preferences. 

Differences Between Sublocade and Suboxone®

When it comes down to comparing Sublocade and Suboxone® for the treatment of OUD, several key differences are important to note:

  • Type of Medication Delivery and How It’s Used: The biggest difference is in how you take them. Sublocade is given as a once-a-month injection, providing a steady amount of medication with just one shot. On the other hand, Suboxone® is a film or tablet you place under your tongue every day.
  • How It Works: Both medications help reduce cravings by acting on the brain’s opioid receptors. However, Suboxone® includes naloxone to prevent misuse, a feature Sublocade doesn’t have.
  • How Long It Lasts: Sublocade offers a steady release of medication over a month, keeping medication levels consistent. Suboxone® requires daily dosing, which can lead to ups and downs in medication levels, depending on how regularly it’s taken.
  • Possible Side Effects: Both can cause side effects like nausea, constipation, and headaches. However, because Sublocade is an injection, it might also cause reactions at the injection site, which you don’t get with Suboxone®.
  • Getting and Paying for Your Medication: Suboxone® is more widely available and may be a more familiar option for many people. Sublocade can be more costly at first but may cut down the need for daily pills or films.

Choosing Between Sublocade and Suboxone®

Deciding whether Sublocade or Suboxone® is right for you comes down to your own needs, lifestyle, and what you’re hoping to achieve in recovery. Each person’s journey is unique, and what works well for one might not be the best for another. Here are some key points to think about:

  • Your Daily Routine and Preferences: If remembering to take medication every day is tough for you, Sublocade’s once-a-month shot could make things a lot easier. But, if you like having daily control over your treatment, you might prefer Suboxone®.
  • Recovery Goals: If you’re looking for consistent help without daily hassle, Sublocade’s long-lasting effect might be what you need. If you feel more comfortable with a treatment you can adjust more frequently, Suboxone®’s daily doses could be a better fit.

Choosing between Sublocade and Suboxone® isn’t just about comparing two treatments. It’s about finding the right approach that fits into your life and supports your recovery goals. Both options have their benefits, and the right choice depends on your personal situation and preferences, guided by advice from healthcare professionals. Remember, moving towards a life without opioid dependence is a journey that requires support, determination, and a treatment plan that’s right for you.

Porch Light Health Can Help

Porch Light Health, serving Colorado and New Mexico, offers a cutting-edge addiction treatment program encompassing Medications for Addiction Treatment (MAT) as part of a holistic strategy for overcoming opioid use disorder. With a focus on the whole person, Porch Light Health addresses both the physical and psychological challenges of addiction, ensuring a compassionate, personalized care pathway tailored to each individual’s recovery needs.

Whether your path includes Sublocade, Suboxone®, or another treatment route, your journey to recovery is deeply personal and incredibly valuable. Remember, you’re not navigating this alone. Porch Light Health is here to guide you as you move toward a hopeful and healthier future.

Choose to take that step today. 

New Patient Registration | Call: 866-394-6123

Frequently Asked Questions (FAQ’s)

Does Sublocade work as well as Suboxone®?

Yes, Sublocade works as effectively as Suboxone® for many individuals with opioid use disorder (OUD). Both medications are designed to reduce cravings and withdrawal symptoms, but their delivery methods differ, catering to diverse patient needs and preferences. Choosing between treatments depends on personal health profiles, adherence, and specific recovery goals.

How long do you stay on Sublocade?

The duration of Sublocade treatment varies for each individual, typically ranging from six months to over a year, based on the patient’s progress. The goal is to provide stable medication support while working on recovery goals. Decisions about the length of treatment are made collaboratively, considering the patient’s health, lifestyle, and long-term recovery plan.

How effective is the Sublocade shot?

The Sublocade shot has proven to be effective in clinical studies and real-world use for reducing opioid cravings and withdrawal symptoms. Its effectiveness is comparable to other MAT options, with the added benefit of monthly dosing.

Resources

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889966/

2. https://www.jsatjournal.com/article/S2949-8759(23)00206-0/fulltext

3. https://www.ncbi.nlm.nih.gov/books/NBK441910/

4. https://journals.lww.com/jan/citation/2018/04000/sublocade__the_once_monthly_buprenorphine.9.aspx

5. https://www.ncbi.nlm.nih.gov/books/NBK459126/

6. https://www.ncbi.nlm.nih.gov/books/NBK441910/

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Suboxone® is a registered trademark of Indivior UK Limited. Porch Light is not affiliated with Indivior UK Limited or its affiliates ("Indivior"), and any reference to it or its intellectual property is for informational purposes only and is not endorsed or sponsored by Indivior.
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