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Opioid Addiction Treatment: Narcan™ vs. Vivitrol™

Jeremy Dubin
Clinically Reviewed By Dr. Jeremy Dubin

Opioid addiction is a growing concern, with overdoses rising by 54% in 2020, accounting for nearly two in three overdose deaths in Colorado. Narcan™ and Vivitrol™ are two pivotal medications in the fight against opioid addiction.

What are Narcan and Vivitrol?

Narcan™ (naloxone) and Vivitrol™ (naltrexone) are both opioid antagonists designed to block the effects of opioids in the brain. These medications play a vital role in both emergency and long-term treatment settings, providing essential tools for managing and reversing the effects of opioid misuse. 

Narcan™ (Naloxone)

Narcan™, known scientifically as naloxone, is a life-saving emergency medication specifically designed to counter the dangerous effects of an opioid overdose. In life-threatening situations where opioids have depressed critical life functions, naloxone acts rapidly to reverse life-threatening effects. Narcan™ is a non-addictive opioid antagonist, meaning it binds to opioid receptors in the brain and displaces opioids, thereby quickly reversing their effects. This is particularly crucial in preventing fatal respiratory depression that opioids can cause.

Vivitrol™ (Naltrexone)

Vivitrol™, or naltrexone, serves a different but equally vital role in opioid addiction treatment. Unlike Narcan, which is used in acute overdose situations, Vivitrol™ is utilized for long-term management of opioid dependence and alcohol use disorder (AUD). Vivitrol is the brand name of injectable naltrexone; the oral tablets, generic naltrexone, are available as well. As mentioned above, Vivitrol™ helps individuals in recovery maintain their sobriety over extended periods by reducing cravings and the chance of relapse. Vivitrol’s™’s efficacy lies in its ability to provide a sustained barrier against opioid effects, which is especially beneficial for individuals who have completed detoxification and are committed to long-term recovery.

How Do Narcan™ and Vivitrol™ Work?

The effectiveness of Narcan™ and Vivitrol™ in treating opioid use lies in their unique mechanisms as opioid antagonists. Here’s a deeper look at how these medications work:

How Narcan™ Works

Narcan™, or naloxone, functions by rapidly attaching itself to the opioid receptors in the brain. These receptors are the same sites where opioids like heroin, morphine, and prescription painkillers bind and produce their effects. When someone overdoses on opioids, these substances can overly depress the body’s respiratory system, leading to potentially fatal breathing problems.

Narcan’s™ binding to these receptors is stronger than that of most opioids, which allows it to effectively knock off and replace the opioids at these receptor sites. By doing so, it quickly reverses the respiratory depression and other life-threatening effects caused by the overdose. This reversal can occur within minutes, making Narcan™ an essential emergency response tool.

How Vivitrol™ Works

Vivitrol™, on the other hand, is a long-acting form of naltrexone. As an opioid antagonist, it works by binding to the same opioid receptors in the brain, but it does not activate them. Instead, it blocks them, preventing opioids from producing their usual euphoric and sedative effects.

This blocking action is crucial in helping individuals who are in recovery from opioid addiction. By preventing the euphoric effects of opioids, Vivitrol™ reduces cravings and the urge to use these substances. This is particularly important for maintaining long-term sobriety and preventing relapse.

Dosing and Dosage

Understanding the dosing and dosage of Narcan™ and Vivitrol™ is crucial for their effective and safe use in treating opioid addiction. Here’s an expanded look at how these medications are typically administered:

Narcan Dosing and Dosage

Naloxone is available in two primary forms: a nasal spray and an injectable solution. Naloxone is available by brand names recognized as Narcan™, Kloxxado™, and Zimhi™. The dosing can vary depending on the brand of drug, severity of the opioid overdose, and the response of the individual.

  • Nasal Spray: The nasal spray is commonly used because of its ease of administration, especially in emergency situations where medical professionals might not be immediately available. The standard dose for the nasal spray is typically 4 mg of naloxone per spray. It’s designed for single use, and no assembly is required. In cases of severe overdose, multiple doses may be required if the first dose does not adequately reverse the symptoms of overdose.
  • Injectable Solution: The injectable form of Naloxone can be administered intravenously, intramuscularly, or subcutaneously. The standard dose is usually 0.4 mg (Narcan™), but this can be adjusted based on medical judgment and the individual’s response. Similar to the nasal spray, additional doses may be needed in severe cases.

Vivitrol™ Dosing and Dosage

Vivitrol™, unlike Narcan™, is used for long-term maintenance rather than emergency intervention. It is administered in a healthcare setting due to its intramuscular injection requirement.

  • Monthly injection: The standard dosage of Vivitrol™ is a 380 mg injection, given once a month. This consistent dosing schedule is important to maintain the medication’s effectiveness in blocking opioid receptors.
  • Post-detoxification requirement: A critical aspect of Vivitrol™ treatment is that it must be initiated only after the individual has gone through opioid detoxification. Starting Vivitrol™ in a person who has not been detoxified can precipitate severe opioid withdrawal symptoms. Therefore, it is usually recommended that an individual be opioid-free for a minimum of 7-10 days before starting Vivitrol™.

If you or someone you know is looking for outpatient addiction treatment services, contact Porch Light Health today. We are committed to providing care to those suffering from substance abuse in a private, respectful environment with a combination of the latest evidence-based treatments. 

Call: 866-394-6123 | New Patient Registration

Side Effects of Vivitrol™ and Narcan™

When considering treatments for opioid addiction, such as Narcan™ and Vivitrol™, it’s important to be aware of potential side effects. While both medications are generally safe, they do come with side effects that should be monitored.

Side Effects of Narcan™

Narcan™, primarily used in emergency situations to reverse opioid overdose, is known for its safety and efficacy. However, it can have some side effects, particularly in individuals with opioid dependence.

  • Withdrawal symptoms: The most notable side effect of Narcan™ in opioid-dependent individuals is the rapid onset of withdrawal symptoms. These symptoms can include nausea, vomiting, sweating, tremors, increased heart rate, and agitation. While these symptoms can be uncomfortable, they are a sign that the medication is effectively reversing the overdose.
  • Other considerations: Narcan™ is generally safe for all ages, including children and pregnant women, in emergency situations. Allergic reactions to Narcan are rare but possible and would require immediate medical attention.

Side Effects of Vivitrol™

Vivitrol™, used for long-term opioid addiction treatment, also has a range of side effects, ranging from mild to serious.

  • Common side effects: Many individuals on Vivitrol™ may experience nausea, headache, dizziness, and muscle cramps. These side effects are usually mild and often decrease over time as the body adjusts to the medication.
  • Serious side effects: More severe side effects of Vivitrol™ can include liver damage or hepatitis. Symptoms of liver damage may include yellowing of the skin or eyes (jaundice), dark urine, light-colored stools, lack of appetite for several days or longer, nausea, or stomach pain. Because of the risk of liver damage, regular monitoring of liver function is recommended while on Vivitrol™.
  • Injection site reactions: Since Vivitrol™ is administered as an injection, some individuals may experience reactions at the injection site, such as pain, redness, or swelling.

Prescription Requirements

When it comes to accessing Narcan™ and Vivitrol™ for opioid addiction treatment, understanding their prescription requirements is necessary. 

Accessing Narcan

Narcan™, or naloxone, has unique accessibility due to its role in emergency overdose situations.

  • Over-the-counter availability: Although it varies by location, Narcan™ is available over the counter (OTC) in many regions, meaning it can be purchased without a prescription. This increased accessibility is a response to the opioid epidemic, allowing individuals, families, and communities to have a potentially life-saving medication readily available. The availability of Narcan™ OTC varies by state and country, reflecting differing regulations and policies.
  • Prescriptions and programs: Despite its OTC status in many areas, healthcare providers can also prescribe Narcan™. Many states and communities have established Narcan distribution programs, often providing the medication at no cost to individuals at risk of opioid overdose or their family members and friends.

Accessing Vivitrol™

Vivitrol™, used for long-term opioid addiction treatment, has different prescription requirements compared to Narcan.

  • Prescription-only medication: Vivitrol™ is available only by prescription and must be administered by a healthcare professional. This requirement is due to its formulation as a long-acting injectable and the need for medical oversight, especially considering its potential for precipitating withdrawal symptoms and liver damage.

Choosing the right treatment depends on individual needs and circumstances. Individuals should consult a healthcare professional to develop an effective and comprehensive treatment plan. Contact Porch Light Health to discuss treatment options for opiate or alcohol use disorder.

Contact Porch Light Health for Support

Porch Light Health, with a network of clinics spanning Colorado and New Mexico, offers comprehensive opioid addiction treatment. Our approach combines immediate intervention with long-term recovery strategies, ensuring each patient receives individualized care.

If you or a loved one is struggling with opioid addiction, contact us for support. Our team is dedicated to providing compassionate, effective treatment to help you on your journey to recovery.

Call: 866-394-6123 | Find a Clinic

Naltrexone and Naloxone FAQs

Are naltrexone and naloxone the same thing?

Naltrexone and naloxone are not the same; they are distinct medications with different purposes. Naltrexone (Vivitrol™) is used for the long-term treatment of opioid and alcohol addiction, while naloxone (Narcan™) is an emergency medication for opioid overdose reversal.

Are Narcan™ and naloxone the same drug?

Yes, Narcan and naloxone refer to the same drug. Narcan is a brand name for naloxone, which is used as an emergency treatment for opioid overdoses.

What is naltrexone the antidote for?

Naltrexone is not an antidote in the traditional sense but is used to prevent relapse for opioid and alcohol addiction. It aids in recovery by blocking the rewarding effects of these substances.

References

  1. Leece, P., Orkin, A., Shahin, R., & Steele, L. S. (2018). Development and implementation of an opioid overdose prevention and response program in Toronto, Ontario. Canadian Journal of Public Health, 109(5-6), 742–750. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753997/
  2. National Center for Biotechnology Information. (2019). Opioid Overdose. In StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK441910/
  3. Colorado Health Institute. (2020). Overdose Dashboard. https://www.coloradohealthinstitute.org/research/2020overdose_dashboard
  4. National Center for Biotechnology Information. (2019). Naltrexone. In StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK534811/
  5. Soyka, M., & Müller, C. A. (2015). Pharmacotherapy of alcoholism – an update on approved and off-label medications. Expert Opinion on Pharmacotherapy, 16(3), 321–332. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308412/
  6. Network for Public Health Law. (2023). Fact Sheet: Naloxone Prescription Mandates 2022 Update. https://www.networkforphl.org/wp-content/uploads/2023/07/Fact-Sheet-Naloxone-Prescription-Mandates-2022-update.pdf
  7. American Journal of Psychiatry. (2022). Update on the Use of Naltrexone in the Treatment of Alcoholism. https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20220821

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